Biomimetic Magnetic Nanocarriers Drive Choline Kinase Alpha Inhibitor inside Cancer Cells for Combined Chemo-Hyperthermia Therapy

Choline kinase α1 (ChoKα1) has become an excellent antitumor target. Among all the inhibitors synthetized, the new compound Ff35 shows an excellent capacity to inhibit ChoKα1 activity. However, soluble Ff35 is also capable of inhibiting choline uptake, making the inhibitor not selective for ChoKα1....

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Pubblicato in:Pharmaceutics
Autori principali: Jabalera, Ylenia, Sola-Leyva, Alberto, Peigneux, Ana, Vurro, Federica, Iglesias, Guillermo R., Vilchez-Garcia, Jesus, Pérez-Prieto, Inmaculada, Aguilar-Troyano, Francisco J., López-Cara, Luisa C., Carrasco-Jiménez, María P., Jimenez-Lopez, Concepcion
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6722936/
https://ncbi.nlm.nih.gov/pubmed/31408964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11080408
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