The Early Phase of β2m Aggregation: An Integrative Computational Study Framed on the D76N Mutant and the ΔN6 Variant

Human β2-microglobulin (b2m) protein is classically associated with dialysis-related amyloidosis (DRA). Recently, the single point mutant D76N was identified as the causative agent of a hereditary systemic amyloidosis affecting visceral organs. To get insight into the early stage of the β2m aggregat...

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Bibliographic Details
Published in:	Biomolecules
Main Authors:	J. S. Loureiro, Rui, Vila-Viçosa, Diogo, Machuqueiro, Miguel, Shakhnovich, Eugene I., F. N. Faísca, Patrícia
Format:	Artigo
Language:	Inglês
Published:	MDPI 2019
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6722664/ https://ncbi.nlm.nih.gov/pubmed/31416179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9080366
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The Early Phase of β2m Aggregation: An Integrative Computational Study Framed on the D76N Mutant and the ΔN6 Variant

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