Efficient generation of Knock-in/Knock-out marmoset embryo via CRISPR/Cas9 gene editing

Genetically modified nonhuman primates (NHP) are useful models for biomedical research. Gene editing technologies have enabled production of target-gene knock-out (KO) NHP models. Target-gene-KO/knock-in (KI) efficiency of CRISPR/Cas9 has not been extensively investigated in marmosets. In this study...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Kumita, Wakako, Sato, Kenya, Suzuki, Yasuhiro, Kurotaki, Yoko, Harada, Takeshi, Zhou, Yang, Kishi, Noriyuki, Sato, Kengo, Aiba, Atsu, Sakakibara, Yasubumi, Feng, Guoping, Okano, Hideyuki, Sasaki, Erika
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6722079/
https://ncbi.nlm.nih.gov/pubmed/31481684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-49110-3
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