טוען...
eIF4G1 and carboxypeptidase E axis dysregulation in O-GlcNAc transferase–deficient pancreatic β-cells contributes to hyperproinsulinemia in mice
An early hallmark of type 2 diabetes is a failure of proinsulin-to-insulin processing in pancreatic β-cells, resulting in hyperproinsulinemia. Proinsulin processing is quite sensitive to nutrient flux, and β-cell–specific deletion of the nutrient-sensing protein modifier OGlcNAc transferase (βOGTKO)...
שמור ב:
| הוצא לאור ב: | J Biol Chem |
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| Main Authors: | , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society for Biochemistry and Molecular Biology
2019
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6721936/ https://ncbi.nlm.nih.gov/pubmed/31300553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008670 |
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