Absence of Uncoupling Protein-3 at Thermoneutrality Impacts Lipid Handling and Energy Homeostasis in Mice

The role of uncoupling protein-3 (UCP3) in energy and lipid metabolism was investigated. Male wild-type (WT) and UCP3-null (KO) mice that were housed at thermoneutrality (30 °C) were used as the animal model. In KO mice, the ability of skeletal muscle mitochondria to oxidize fatty acids (but not pyr...

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Published in:Cells
Main Authors: Lombardi, Assunta, Busiello, Rosa Anna, De Matteis, Rita, Lionetti, Lillà, Savarese, Sabrina, Moreno, Maria, Gentile, Alessandra, Silvestri, Elena, Senese, Rosalba, de Lange, Pieter, Cioffi, Federica, Lanni, Antonia, Goglia, Fernando
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721699/
https://ncbi.nlm.nih.gov/pubmed/31426456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8080916
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