Cancer-Derived VEGF-C Increases Chemokine Production in Lymphatic Endothelial Cells to Promote CXCR2-Dependent Cancer Invasion and MDSC Recruitment

Breast cancer-derived vascular endothelial growth factor-C (VEGF-C) has been shown to enhance lymphangiogenesis in lymph nodes to accelerate cancer metastasis. However, the remodeling of lymph node microenvironments by VEGF-C remains elusive. By in vivo selection, we established a subline (named as...

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Udgivet i:Cancers (Basel)
Main Authors: Chen, Jing-Yi, Lai, You-Syuan, Chu, Pei-Yi, Chan, Shih-Hsuan, Wang, Lu-Hai, Hung, Wen-Chun
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721484/
https://ncbi.nlm.nih.gov/pubmed/31390756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11081120
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