Type 1 Sodium Calcium Exchanger Forms a Complex with Carbonic Anhydrase IX and Via Reverse Mode Activity Contributes to pH Control in Hypoxic Tumors

Hypoxia and acidosis are among the key microenvironmental factors that contribute to cancer progression. We have explored a possibility that the type 1Na(+)/Ca(2+) exchanger (NCX1) is involved in pH control in hypoxic tumors. We focused on changes in intracellular pH, co-localization of NCX1, carbon...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Liskova, Veronika, Hudecova, Sona, Lencesova, Lubomira, Iuliano, Filippo, Sirova, Marta, Ondrias, Karol, Pastorekova, Silvia, Krizanova, Olga
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721473/
https://ncbi.nlm.nih.gov/pubmed/31395807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11081139
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