EP300 and SIRT1/6 Co-Regulate Lapatinib Sensitivity Via Modulating FOXO3-Acetylation and Activity in Breast Cancer

Forkhead Box O3 (FOXO3) is a tumor suppressor whose activity is fine-tuned by post-translational modifications (PTMs). In this study, using the BT474 breast cancer cells and a recently established lapatinib resistant (BT474-Lap(R)) cell line, we observed that higher FOXO3 and acetylated (Ac)-FOXO3 l...

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Dettagli Bibliografici
Pubblicato in:Cancers (Basel)
Autori principali: Mahmud, Zimam, Gomes, Ana R., Lee, Hee Jin, Aimjongjun, Sathid, Jiramongkol, Yannasittha, Yao, Shang, Zona, Stefania, Alasiri, Glowi, Gong, Gyungyub, Yagüe, Ernesto, Lam, Eric W.-F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721388/
https://ncbi.nlm.nih.gov/pubmed/31357743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11081067
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