Reciprocal regulation between GCN2 (eIF2AK4) and PERK (eIF2AK3) through the JNK-FOXO3 axis to modulate cancer drug resistance and clonal survival

Pharmaceutical inhibitors of the endoplasmic reticulum (ER)-stress modulator PERK (eIF2AK3) have demonstrated anticancer activities in combination therapies, but their effectiveness as a single agent is limited, suggesting the existence of possible compensatory cellular responses. To explore the pot...

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Publicado no:Mol Cell Endocrinol
Main Authors: Alasiri, Glowi, Jiramongkol, Yannasittha, Trakansuebkul, Sasanan, Ke, Hui-Ling, Mahmud, Zimam, Intuyod, Kitti, Lam, Eric W.-F.
Formato: Artigo
Idioma:Inglês
Publicado em: North Holland Publishing 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7493713/
https://ncbi.nlm.nih.gov/pubmed/32615282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2020.110932
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