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Synthesis and Antiproliferative Activity of Novel A-Ring Cleaved Glycyrrhetinic Acid Derivatives

A series of new glycyrrhetinic acid derivatives was synthesized via the opening of its ring A along with the coupling of an amino acid. The antiproliferative activity of the derivatives was evaluated against a panel of nine human cancer cell lines. Compound 17 was the most active compound, with an I...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Alho, Daniela P.S., Salvador, Jorge A.R., Cascante, Marta, Marin, Silvia
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6721064/
https://ncbi.nlm.nih.gov/pubmed/31416117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24162938
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