CDK5 neutralizes the tumor suppressing effect of BIN1 via mediating phosphorylation of c-MYC at Ser-62 site in NSCLC

BACKGROUND: Bridging integrator 1 (BIN1) has showed outstanding tumor-suppressive potential via inhibiting c-MYC-mediated tumorigenesis. However, a frequent phosphorylation of c-MYC at Ser-62 site could block the BIN1/c-MYC interaction and limits the tumor-suppressive effect of BIN1. Cyclin-dependen...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Cancer Cell Int
Main Authors: Zhang, Xiangyu, Wang, Jiali, Jia, Yunlong, Liu, Tianxu, Wang, Mengjie, Lv, Wei, Zhang, Rong, Shi, Juan, Liu, Lihua
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Primary Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6720419/
https://ncbi.nlm.nih.gov/pubmed/31496920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-019-0952-5
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker