Methylation decreases the Bin1 tumor suppressor in ESCC and restoration by decitabine inhibits the epithelial mesenchymal transition

Bridging integrator-1 (Bin1), as a tumor suppressor, is frequently attenuated or even abolished in multiple primary cancers. A reduced expression of Bin1 caused by DNA methylation, has been reported in breast and prostate cancers. However, the methylation status of Bin1 and potent biological functio...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Wang, Xuexiao, Wang, Jiali, Jia, Yunlong, Wang, Yu, Han, Xiaonan, Duan, Yuqing, Lv, Wei, Ma, Ming, Liu, Lihua
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2017
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386712/
https://ncbi.nlm.nih.gov/pubmed/28152502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14914
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