Bioinformatics and DNA-extraction strategies to reliably detect genetic variants from FFPE breast tissue samples

BACKGROUND: Archived formalin fixed paraffin embedded (FFPE) samples are valuable clinical resources to examine clinically relevant morphology features and also to study genetic changes. However, DNA quality and quantity of FFPE samples are often sub-optimal, and resulting NGS-based genetics variant...

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Publicado en:BMC Genomics
Main Authors: Bhagwate, Aditya Vijay, Liu, Yuanhang, Winham, Stacey J., McDonough, Samantha J., Stallings-Mann, Melody L., Heinzen, Ethan P., Davila, Jaime I., Vierkant, Robert A., Hoskin, Tanya L., Frost, Marlene, Carter, Jodi M., Radisky, Derek C., Cunningham, Julie M., Degnim, Amy C., Wang, Chen
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6720378/
https://ncbi.nlm.nih.gov/pubmed/31477010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-019-6056-8
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