Bioinformatics and DNA-extraction strategies to reliably detect genetic variants from FFPE breast tissue samples

BACKGROUND: Archived formalin fixed paraffin embedded (FFPE) samples are valuable clinical resources to examine clinically relevant morphology features and also to study genetic changes. However, DNA quality and quantity of FFPE samples are often sub-optimal, and resulting NGS-based genetics variant...

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Detalhes bibliográficos
Publicado no:BMC Genomics
Main Authors: Bhagwate, Aditya Vijay, Liu, Yuanhang, Winham, Stacey J., McDonough, Samantha J., Stallings-Mann, Melody L., Heinzen, Ethan P., Davila, Jaime I., Vierkant, Robert A., Hoskin, Tanya L., Frost, Marlene, Carter, Jodi M., Radisky, Derek C., Cunningham, Julie M., Degnim, Amy C., Wang, Chen
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6720378/
https://ncbi.nlm.nih.gov/pubmed/31477010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-019-6056-8
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