The RNA hairpin binder TRIM71 modulates alternative splicing by repressing MBNL1

TRIM71/LIN-41, a phylogenetically conserved regulator of development, controls stem cell fates. Mammalian TRIM71 exhibits both RNA-binding and protein ubiquitylation activities, but the functional contribution of either activity and relevant primary targets remain poorly understood. Here, we demonst...

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Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Welte, Thomas, Tuck, Alex C., Papasaikas, Panagiotis, Carl, Sarah H., Flemr, Matyas, Knuckles, Philip, Rankova, Aneliya, Bühler, Marc, Großhans, Helge
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2019
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719626/
https://ncbi.nlm.nih.gov/pubmed/31371437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.328492.119
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