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Basal CHK1 activity safeguards its stability to maintain intrinsic S-phase checkpoint functions
The DNA replication machinery frequently encounters impediments that slow replication fork progression and threaten timely and error-free replication. The CHK1 protein kinase is essential to deal with replication stress (RS) and ensure genome integrity and cell survival, yet how basal levels and act...
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| Publié dans: | J Cell Biol |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Rockefeller University Press
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6719454/ https://ncbi.nlm.nih.gov/pubmed/31366665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201902085 |
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