Fusion of Lysostaphin to an Albumin Binding Domain Prolongs Its Half-Life and Bactericidal Activity in the Systemic Circulation

Antibacterial lysins are promising proteins that are active against both antibiotic-susceptible and antibiotic-resistant bacterial strains. However, a major limitation of antibacterial lysins is their fast elimination from systemic circulation. PEGylation increases the plasma half-life of lysins but...

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Publicat a:Molecules
Autors principals: Grishin, Alexander V., Shestak, Nikita V., Lavrova, Natalia V., Lyashchuk, Alexander M., Popova, Liubov I., Strukova, Natalia V., Generalova, Maria S., Ryazanova, Anna V., Polyakov, Nikita B., Galushkina, Zoya M., Soboleva, Lyubov A., Boksha, Irina S., Karyagina, Anna S., Lunin, Vladimir G.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719061/
https://ncbi.nlm.nih.gov/pubmed/31395814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24162892
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