Fusion of Lysostaphin to an Albumin Binding Domain Prolongs Its Half-Life and Bactericidal Activity in the Systemic Circulation

Antibacterial lysins are promising proteins that are active against both antibiotic-susceptible and antibiotic-resistant bacterial strains. However, a major limitation of antibacterial lysins is their fast elimination from systemic circulation. PEGylation increases the plasma half-life of lysins but...

詳細記述

保存先:
書誌詳細
出版年:Molecules
主要な著者: Grishin, Alexander V., Shestak, Nikita V., Lavrova, Natalia V., Lyashchuk, Alexander M., Popova, Liubov I., Strukova, Natalia V., Generalova, Maria S., Ryazanova, Anna V., Polyakov, Nikita B., Galushkina, Zoya M., Soboleva, Lyubov A., Boksha, Irina S., Karyagina, Anna S., Lunin, Vladimir G.
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719061/
https://ncbi.nlm.nih.gov/pubmed/31395814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24162892
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