Fusion of Lysostaphin to an Albumin Binding Domain Prolongs Its Half-Life and Bactericidal Activity in the Systemic Circulation

Antibacterial lysins are promising proteins that are active against both antibiotic-susceptible and antibiotic-resistant bacterial strains. However, a major limitation of antibacterial lysins is their fast elimination from systemic circulation. PEGylation increases the plasma half-life of lysins but...

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Bibliografiset tiedot
Julkaisussa:Molecules
Päätekijät: Grishin, Alexander V., Shestak, Nikita V., Lavrova, Natalia V., Lyashchuk, Alexander M., Popova, Liubov I., Strukova, Natalia V., Generalova, Maria S., Ryazanova, Anna V., Polyakov, Nikita B., Galushkina, Zoya M., Soboleva, Lyubov A., Boksha, Irina S., Karyagina, Anna S., Lunin, Vladimir G.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI 2019
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719061/
https://ncbi.nlm.nih.gov/pubmed/31395814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24162892
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