Fusion of Lysostaphin to an Albumin Binding Domain Prolongs Its Half-Life and Bactericidal Activity in the Systemic Circulation

Antibacterial lysins are promising proteins that are active against both antibiotic-susceptible and antibiotic-resistant bacterial strains. However, a major limitation of antibacterial lysins is their fast elimination from systemic circulation. PEGylation increases the plasma half-life of lysins but...

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Pubblicato in:Molecules
Autori principali: Grishin, Alexander V., Shestak, Nikita V., Lavrova, Natalia V., Lyashchuk, Alexander M., Popova, Liubov I., Strukova, Natalia V., Generalova, Maria S., Ryazanova, Anna V., Polyakov, Nikita B., Galushkina, Zoya M., Soboleva, Lyubov A., Boksha, Irina S., Karyagina, Anna S., Lunin, Vladimir G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719061/
https://ncbi.nlm.nih.gov/pubmed/31395814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24162892
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