Temporary Reduction of Membrane CD4 with the Antioxidant MnTBAP Is Sufficient to Prevent Immune Responses Induced by Gene Transfer

Unexpectedly, the synthetic antioxidant MnTBAP was found to cause a rapid and reversible downregulation of CD4 on T cells in vitro and in vivo. This effect resulted from the internalization of membrane CD4 T cell molecules into clathrin-coated pits and involved disruption of the CD4/p56(Lck) complex...

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Pubblicato in:Mol Ther Methods Clin Dev
Autori principali: Da Rocha, Sylvie, Bigot, Jérémy, Onodi, Fanny, Cosette, Jérémie, Corre, Guillaume, Poupiot, Jérôme, Fenard, David, Gjata, Bernard, Galy, Anne, Neildez-Nguyen, Thi My Anh
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718808/
https://ncbi.nlm.nih.gov/pubmed/31497619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.06.011
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