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Neuronal‐specific proteasome augmentation via Prosβ5 overexpression extends lifespan and reduces age‐related cognitive decline

Cognitive function declines with age throughout the animal kingdom, and increasing evidence shows that disruption of the proteasome system contributes to this deterioration. The proteasome has important roles in multiple aspects of the nervous system, including synapse function and plasticity, as we...

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Podrobná bibliografie
Vydáno v:Aging Cell
Hlavní autoři: Munkácsy, Erin, Chocron, E. Sandra, Quintanilla, Laura, Gendron, Christi M., Pletcher, Scott D., Pickering, Andrew M.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718538/
https://ncbi.nlm.nih.gov/pubmed/31334599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13005
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