Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes

Werner Syndrome (WS) is an adult‐onset segmental progeroid syndrome. Bisulfite pyrosequencing of repetitive DNA families revealed comparable blood DNA methylation levels between classical (18 WRN‐mutant) or atypical WS (3 LMNA‐mutant and 3 POLD1‐mutant) patients and age‐ and sex‐matched controls. WS...

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Veröffentlicht in:Aging Cell
Hauptverfasser: Maierhofer, Anna, Flunkert, Julia, Oshima, Junko, Martin, George M., Poot, Martin, Nanda, Indrajit, Dittrich, Marcus, Müller, Tobias, Haaf, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718529/
https://ncbi.nlm.nih.gov/pubmed/31259468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12995
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