Rag1 immunodeficiency‐induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress

In mammals, recombination activating gene 1 (RAG1) plays a crucial role in adaptive immunity, generating a vast range of immunoglobulins. Rag1 (−/−) zebrafish (Danio rerio) are viable and reach adulthood without obvious signs of infectious disease in standard nonsterile conditions, suggesting that i...

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Bibliografski detalji
Izdano u:Aging Cell
Glavni autori: Novoa, Beatriz, Pereiro, Patricia, López‐Muñoz, Azucena, Varela, Mónica, Forn‐Cuní, Gabriel, Anchelin, Monique, Dios, Sonia, Romero, Alejandro, Martinez‐López, Alicia, Medina‐Gali, Regla María, Collado, Manuel, Coll, Julio, Estepa, Amparo, Cayuela, María Luisa, Mulero, Victoriano, Figueras, Antonio
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718522/
https://ncbi.nlm.nih.gov/pubmed/31348603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13020
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