Zebra Fish Lacking Adaptive Immunity Acquire an Antiviral Alert State Characterized by Upregulated Gene Expression of Apoptosis, Multigene Families, and Interferon-Related Genes

To investigate fish innate immunity, we have conducted organ and cell immune-related transcriptomic as well as immunohistologic analysis in mutant zebra fish (Danio rerio) lacking adaptive immunity (rag1(−/−)) at different developmental stages (egg, larvae, and adult), before and after infection wit...

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Bibliographic Details
Published in:Front Immunol
Main Authors: García-Valtanen, Pablo, Martínez-López, Alicia, López-Muñoz, Azucena, Bello-Perez, Melissa, Medina-Gali, Regla M., Ortega-Villaizán, María del Mar, Varela, Monica, Figueras, Antonio, Mulero, Víctoriano, Novoa, Beatriz, Estepa, Amparo, Coll, Julio
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5303895/
https://ncbi.nlm.nih.gov/pubmed/28243233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00121
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