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Engineered ribosomes with tethered subunits for expanding biological function

Ribo-T is a ribosome with covalently tethered subunits where core 16S and 23S ribosomal RNAs form a single chimeric molecule. Ribo-T makes possible a functionally orthogonal ribosome–mRNA system in cells. Unfortunately, use of Ribo-T has been limited because of low activity of its original version....

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Carlson, Erik D., d’Aquino, Anne E., Kim, Do Soon, Fulk, Emily M., Hoang, Kim, Szal, Teresa, Mankin, Alexander S., Jewett, Michael C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718428/
https://ncbi.nlm.nih.gov/pubmed/31477696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11427-y
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