Mevalonate pathway activity as a determinant of radiation sensitivity in head and neck cancer

Radioresistance is a major hurdle in the treatment of head and neck squamous cell carcinoma (HNSCC). Here, we report that concomitant treatment of HNSCCs with radiotherapy and mevalonate pathway inhibitors (statins) may overcome resistance. Proteomic profiling and comparison of radioresistant to rad...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Ricco, Natalia, Flor, Amy, Wolfgeher, Don, Efimova, Elena V., Ramamurthy, Aishwarya, Appelbe, Oliver K., Brinkman, Jacqueline, Truman, Andrew W., Spiotto, Michael T., Kron, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717759/
https://ncbi.nlm.nih.gov/pubmed/31225926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12535
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