Targeting of DDR1 with antibody‐drug conjugates has antitumor effects in a mouse model of colon carcinoma

DDR1 has been identified as a cancer‐associated receptor tyrosine kinase that is highly expressed in several malignancies relative to normal tissues. Clinically approved multi‐kinase inhibitors, such as nilotinib, inhibit DDR1‐mediated tumor growth in xenograft models, suggesting DDR1 might be a pot...

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Vydáno v:Mol Oncol
Hlavní autoři: Tao, Yiran, Wang, Ruixue, Lai, Qinhuai, Wu, Mengdan, Wang, Yuxi, Jiang, Xiaohua, Zeng, Lishi, Zhou, Shijie, Li, Zhongping, Yang, Tinghan, Yao, Yuqin, Wu, Yangping, Yu, Lin, Fu, Yuyin, Lai, Weirong, Peng, Yujia, Lu, Ying, Zhang, Zhixiong, Guo, Cuiyu, Zhang, Guangbing, Gou, Lantu, Yang, Jinliang
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717758/
https://ncbi.nlm.nih.gov/pubmed/31116512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12520
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