Targeting of DDR1 with antibody‐drug conjugates has antitumor effects in a mouse model of colon carcinoma

DDR1 has been identified as a cancer‐associated receptor tyrosine kinase that is highly expressed in several malignancies relative to normal tissues. Clinically approved multi‐kinase inhibitors, such as nilotinib, inhibit DDR1‐mediated tumor growth in xenograft models, suggesting DDR1 might be a pot...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Tao, Yiran, Wang, Ruixue, Lai, Qinhuai, Wu, Mengdan, Wang, Yuxi, Jiang, Xiaohua, Zeng, Lishi, Zhou, Shijie, Li, Zhongping, Yang, Tinghan, Yao, Yuqin, Wu, Yangping, Yu, Lin, Fu, Yuyin, Lai, Weirong, Peng, Yujia, Lu, Ying, Zhang, Zhixiong, Guo, Cuiyu, Zhang, Guangbing, Gou, Lantu, Yang, Jinliang
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717758/
https://ncbi.nlm.nih.gov/pubmed/31116512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12520
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