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Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis

Loss-of-function mutations in the ATP-binding cassette (ABC) transporter of the inner mitochondrial membrane, ABCB7, cause X-linked sideroblastic anemia with ataxia, a phenotype that remains largely unexplained by the proposed role of ABCB7 in exporting a special sulfur species for use in cytosolic...

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Detalhes bibliográficos
Publicado no:Haematologica
Main Authors: Maio, Nunziata, Kim, Ki Soon, Holmes-Hampton, Gregory, Singh, Anamika, Rouault, Tracey A.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717564/
https://ncbi.nlm.nih.gov/pubmed/30765471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.214320
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