Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site

Ubiquitin (Ub)-mediated proteolysis is a fundamental mechanism used by eukaryotic cells to maintain homeostasis and protein quality, and to control timing in biological processes. Two essential aspects of Ub regulation are conjugation through E1-E2-E3 enzymatic cascades and recognition by Ub-binding...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Watson, Edmond R., Grace, Christy R. R., Zhang, Wei, Miller, Darcie J., Davidson, Iain F., Prabu, J. Rajan, Yu, Shanshan, Bolhuis, Derek L., Kulko, Elizaveta T., Vollrath, Ronnald, Haselbach, David, Stark, Holger, Peters, Jan-Michael, Brown, Nicholas G., Sidhu, Sachdev S., Schulman, Brenda A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2019
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717256/
https://ncbi.nlm.nih.gov/pubmed/31350353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902889116
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