Gene Expression and Missplicing in the Corneal Endothelium of Patients With a TCF4 Trinucleotide Repeat Expansion Without Fuchs' Endothelial Corneal Dystrophy

PURPOSE: CTG trinucleotide repeat (TNR) expansion in an intron of the TCF4 gene is the most common genetic variant associated with Fuchs' endothelial corneal dystrophy (FECD). Although several mechanisms have been implicated in the disease process, their exact pathophysiologic importance is unc...

Full description

Saved in:
Bibliographic Details
Published in:Invest Ophthalmol Vis Sci
Main Authors: Wieben, Eric D., Baratz, Keith H., Aleff, Ross A., Kalari, Krishna R., Tang, Xiaojia, Maguire, Leo J., Patel, Sanjay V., Fautsch, Michael P.
Format: Artigo
Language:Inglês
Published: The Association for Research in Vision and Ophthalmology 2019
Subjects:
Cornea
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6716950/
https://ncbi.nlm.nih.gov/pubmed/31469403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.19-27689
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items