Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43(G298S) ALS mouse model

BACKGROUND: In vivo diffusion tensor imaging (DTI) of the mouse brain was used to identify TDP-43 associated alterations in a mouse model for amyotrophic lateral sclerosis (ALS). METHODS: Ten mice with TDP-43(G298S) overexpression under control of the Thy1.2 promoter and 10 wild type (wt) underwent...

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Detalles Bibliográficos
Publicado en:Transl Neurodegener
Main Authors: Müller, Hans-Peter, Brenner, David, Roselli, Francesco, Wiesner, Diana, Abaei, Alireza, Gorges, Martin, Danzer, Karin M., Ludolph, Albert C., Tsao, William, Wong, Philip C., Rasche, Volker, Weishaupt, Jochen H., Kassubek, Jan
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2019
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6716821/
https://ncbi.nlm.nih.gov/pubmed/31485326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-019-0163-y
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