Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells

The glucagon-like peptide-1 receptor (GLP-1R), a key pharmacological target in type 2 diabetes (T2D) and obesity, undergoes rapid endocytosis after stimulation by endogenous and therapeutic agonists. We have previously highlighted the relevance of this process in fine-tuning GLP-1R responses in panc...

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Detaylı Bibliyografya
Yayımlandı:PLoS Biol
Asıl Yazarlar: Buenaventura, Teresa, Bitsi, Stavroula, Laughlin, William E., Burgoyne, Thomas, Lyu, Zekun, Oqua, Affiong I., Norman, Hannah, McGlone, Emma R., Klymchenko, Andrey S., Corrêa, Ivan R., Walker, Abigail, Inoue, Asuka, Hanyaloglu, Aylin, Grimes, Jak, Koszegi, Zsombor, Calebiro, Davide, Rutter, Guy A., Bloom, Stephen R., Jones, Ben, Tomas, Alejandra
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6716783/
https://ncbi.nlm.nih.gov/pubmed/31430273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000097
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