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Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells
The glucagon-like peptide-1 receptor (GLP-1R), a key pharmacological target in type 2 diabetes (T2D) and obesity, undergoes rapid endocytosis after stimulation by endogenous and therapeutic agonists. We have previously highlighted the relevance of this process in fine-tuning GLP-1R responses in panc...
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| Publicado no: | PLoS Biol |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6716783/ https://ncbi.nlm.nih.gov/pubmed/31430273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000097 |
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