Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells

The glucagon-like peptide-1 receptor (GLP-1R), a key pharmacological target in type 2 diabetes (T2D) and obesity, undergoes rapid endocytosis after stimulation by endogenous and therapeutic agonists. We have previously highlighted the relevance of this process in fine-tuning GLP-1R responses in panc...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS Biol
Päätekijät: Buenaventura, Teresa, Bitsi, Stavroula, Laughlin, William E., Burgoyne, Thomas, Lyu, Zekun, Oqua, Affiong I., Norman, Hannah, McGlone, Emma R., Klymchenko, Andrey S., Corrêa, Ivan R., Walker, Abigail, Inoue, Asuka, Hanyaloglu, Aylin, Grimes, Jak, Koszegi, Zsombor, Calebiro, Davide, Rutter, Guy A., Bloom, Stephen R., Jones, Ben, Tomas, Alejandra
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2019
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6716783/
https://ncbi.nlm.nih.gov/pubmed/31430273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000097
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