Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells

The glucagon-like peptide-1 receptor (GLP-1R), a key pharmacological target in type 2 diabetes (T2D) and obesity, undergoes rapid endocytosis after stimulation by endogenous and therapeutic agonists. We have previously highlighted the relevance of this process in fine-tuning GLP-1R responses in panc...

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Publicado no:PLoS Biol
Main Authors: Buenaventura, Teresa, Bitsi, Stavroula, Laughlin, William E., Burgoyne, Thomas, Lyu, Zekun, Oqua, Affiong I., Norman, Hannah, McGlone, Emma R., Klymchenko, Andrey S., Corrêa, Ivan R., Walker, Abigail, Inoue, Asuka, Hanyaloglu, Aylin, Grimes, Jak, Koszegi, Zsombor, Calebiro, Davide, Rutter, Guy A., Bloom, Stephen R., Jones, Ben, Tomas, Alejandra
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6716783/
https://ncbi.nlm.nih.gov/pubmed/31430273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000097
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