Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development

Alzheimer’s disease (AD) is a large and increasing unmet medical need with no disease-modifying treatment currently available. Genetic evidence from genome-wide association studies (GWASs) and gene network analysis has clearly revealed a key role of the innate immune system in the brain, of which mi...

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Vydáno v:Front Pharmacol
Hlavní autoři: Biber, Knut, Bhattacharya, Anindya, Campbell, Brian M., Piro, Justin R., Rohe, Michael, Staal, Roland G.W., Talanian, Robert V., Möller, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6716448/
https://ncbi.nlm.nih.gov/pubmed/31507408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00840
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