Patchy Amphiphilic Dendrimers Bind Adenovirus and Control Its Host Interactions and in Vivo Distribution

[Image: see text] The surface of proteins is heterogeneous with sophisticated but precise hydrophobic and hydrophilic patches, which is essential for their diverse biological functions. To emulate such distinct surface patterns on macromolecules, we used rigid spherical synthetic dendrimers (polyphe...

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Veröffentlicht in:ACS Nano
Hauptverfasser: Wu, Yuzhou, Li, Longjie, Frank, Larissa, Wagner, Jessica, Andreozzi, Patrizia, Hammer, Brenton, D’Alicarnasso, Marco, Pelliccia, Maria, Liu, Weina, Chakrabortty, Sabyasachi, Krol, Silke, Simon, Johanna, Landfester, Katharina, Kuan, Seah Ling, Stellacci, Francesco, Müllen, Klaus, Kreppel, Florian, Weil, Tanja
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2019
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6716120/
https://ncbi.nlm.nih.gov/pubmed/31322856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.9b01484
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