Miltefosine treatment reduces visceral hypersensitivity in a rat model for irritable bowel syndrome via multiple mechanisms

Irritable bowel syndrome (IBS) is a heterogenic, functional gastrointestinal disorder of the gut-brain axis characterized by altered bowel habit and abdominal pain. Preclinical and clinical results suggested that, in part of these patients, pain may result from fungal induced release of mast cell de...

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Udgivet i:Sci Rep
Main Authors: Botschuijver, Sara, van Diest, Sophie A., van Thiel, Isabelle A. M., Saia, Rafael S., Strik, Anne S., Yu, Zhumei, Maria-Ferreira, Daniele, Welting, Olaf, Keszthelyi, Daniel, Jennings, Gary, Heinsbroek, Sigrid E. M., Elferink, Ronald P. Oude, Schuren, Frank H. J., de Jonge, Wouter J., van den Wijngaard, René M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715706/
https://ncbi.nlm.nih.gov/pubmed/31467355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-49096-y
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