Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants

Organisms must respond to hypoxia to preserve oxygen homeostasis. We identify a thiol oxidase, previously assigned as cysteamine (2-aminoethanethiol) dioxygenase (ADO), as a high K(m)O(2) N-terminal cysteine dioxygenase that transduces the oxygen-regulated stability of proteins by the N-degron pathw...

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Publicado no:Science
Main Authors: Masson, Norma, Keeley, Thomas P., Giuntoli, Beatrice, White, Mark D., Puerta, Mikel Lavilla, Perata, Pierdomenico, Hopkinson, Richard J., Flashman, Emily, Licausi, Francesco, Ratcliffe, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715447/
https://ncbi.nlm.nih.gov/pubmed/31273118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw0112
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