Chikungunya Virus Vaccine Candidates with Decreased Mutational Robustness Are Attenuated In Vivo and Have Compromised Transmissibility

Chikungunya virus (CHIKV) is a reemerged arbovirus, a member of the Togaviridae family. It circulates through mosquito vectors mainly of the Aedes family and a mammalian host. CHIKV causes chikungunya fever, a mild to severe disease characterized by arthralgia, with some fatal outcomes described. In...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Carrau, Lucía, Rezelj, Veronica V., Noval, María G., Levi, Laura I., Megrian, Daniela, Blanc, Herve, Weger-Lucarelli, James, Moratorio, Gonzalo, Stapleford, Kenneth A., Vignuzzi, Marco
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6714818/
https://ncbi.nlm.nih.gov/pubmed/31270226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00775-19
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