Procyanidin B2 inhibits the activation of hepatic stellate cells and angiogenesis via the Hedgehog pathway during liver fibrosis

BACKGROUND: Liver fibrosis is a wound‐healing process of liver featured by the over‐deposition of extracellular matrix (ECM) and angiogenesis. However, the effective treatment is lacking. Procyanidin B2 (PB2) is a flavonoid extract abundant in grape seeds with anti‐oxidant, anti‐inflammatory and ant...

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Veröffentlicht in:J Cell Mol Med
Hauptverfasser: Feng, Jiao, Wang, Chengfen, Liu, Tong, Li, Jingjing, Wu, Liwei, Yu, Qiang, Li, Sainan, Zhou, Yuting, Zhang, Jie, Chen, Jiaojiao, Ji, Jie, Chen, Kan, Mao, Yuqing, Wang, Fan, Dai, Weiqi, Fan, Xiaoming, Wu, Jianye, Guo, Chuanyong
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6714206/
https://ncbi.nlm.nih.gov/pubmed/31328391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14543
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