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Polycystin‐1 affects cancer cell behaviour and interacts with mTOR and Jak signalling pathways in cancer cell lines

Polycystic Kidney Disease (PKD), which is attributable to mutations in the PKD1 and PKD2 genes encoding polycystin‐1 (PC1) and polycystin‐2 (PC2) respectively, shares common cellular defects with cancer, such as uncontrolled cell proliferation, abnormal differentiation and increased apoptosis. Inter...

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Bibliographic Details
Published in:J Cell Mol Med
Main Authors: Papavassiliou, Kostas A., Zoi, Ilianna, Gargalionis, Antonios N., Koutsilieris, Michael
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6714176/
https://ncbi.nlm.nih.gov/pubmed/31251475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14506
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