GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling

The β-catenin mutation is frequently observed in hepatoblastoma (HB), but the underlying mechanism by which Wnt/β-catenin signaling induces HB tumor formation is unknown. Here we show that expression of growth regulation by estrogen in breast cancer 1 (GREB1) depends on Wnt/β-catenin signaling in HB...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Matsumoto, Shinji, Yamamichi, Taku, Shinzawa, Koei, Kasahara, Yuuya, Nojima, Satoshi, Kodama, Takahiro, Obika, Satoshi, Takehara, Tetsuo, Morii, Eiichi, Okuyama, Hiroomi, Kikuchi, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713762/
https://ncbi.nlm.nih.gov/pubmed/31462641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11533-x
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