Interrogation of a live-attenuated enterotoxigenic Escherichia coli vaccine highlights features unique to wild-type infection

Enterotoxigenic Escherichia coli (ETEC) infections are a common cause of severe diarrheal illness in low- and middle-income countries. The live-attenuated ACE527 ETEC vaccine, adjuvanted with double mutant heat-labile toxin (dmLT), affords clear but partial protection against ETEC challenge in human...

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Detalhes bibliográficos
Publicado no:NPJ Vaccines
Main Authors: Chakraborty, Subhra, Randall, Arlo, Vickers, Tim J., Molina, Doug, Harro, Clayton D., DeNearing, Barbara, Brubaker, Jessica, Sack, David A., Bourgeois, A. Louis, Felgner, Philip L., Liang, Xiaowu, Mani, Sachin, Wenzel, Heather, Townsend, R. Reid, Gilmore, Petra E., Darsley, Michael J., Rasko, David A., Fleckenstein, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713706/
https://ncbi.nlm.nih.gov/pubmed/31482013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-019-0131-7
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