Covalently tethering siRNA to hydrogels for localized, controlled release and gene silencing

Small interfering RNA (siRNA) has found many applications in tissue regeneration and disease therapeutics. Effective and localized siRNA delivery remains challenging, reducing its therapeutic potential. Here, we report a strategy to control and prolong siRNA release by directly tethering transfectio...

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Bibliografiske detaljer
Udgivet i:Sci Adv
Main Authors: Nguyen, Minh Khanh, Huynh, Cong Truc, Gilewski, Alex, Wilner, Samantha E., Maier, Keith E., Kwon, Nicholas, Levy, Mathew, Alsberg, Eben
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713499/
https://ncbi.nlm.nih.gov/pubmed/31489374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax0801
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