Covalently tethering siRNA to hydrogels for localized, controlled release and gene silencing

Small interfering RNA (siRNA) has found many applications in tissue regeneration and disease therapeutics. Effective and localized siRNA delivery remains challenging, reducing its therapeutic potential. Here, we report a strategy to control and prolong siRNA release by directly tethering transfectio...

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Pubblicato in:Sci Adv
Autori principali: Nguyen, Minh Khanh, Huynh, Cong Truc, Gilewski, Alex, Wilner, Samantha E., Maier, Keith E., Kwon, Nicholas, Levy, Mathew, Alsberg, Eben
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2019
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713499/
https://ncbi.nlm.nih.gov/pubmed/31489374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax0801
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