Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance

Only a subset of cancer patients respond to T-cell checkpoint inhibitors, highlighting the need for alternative immunotherapeutics. We performed CRISPR-Cas9 screens in a leukemia cell line to identify perturbations that enhance natural killer effector functions. Our screens defined critical componen...

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Dettagli Bibliografici
Pubblicato in:eLife
Autori principali: Pech, Matthew F, Fong, Linda E, Villalta, Jacqueline E, Chan, Leanne JG, Kharbanda, Samir, O'Brien, Jonathon J, McAllister, Fiona E, Firestone, Ari J, Jan, Calvin H, Settleman, Jeffrey
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2019
Soggetti:
Cancer Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713475/
https://ncbi.nlm.nih.gov/pubmed/31452512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47362
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