Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model

The apolipoprotein ε4 allele (APOE4) is the strongest genetic risk factor for Alzheimer’s disease (AD). APOE4 carriers develop systemic metabolic dysfunction decades before showing AD symptoms. Accumulating evidence shows that the metabolic dysfunction accelerates AD development, including exacerbat...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hoffman, Jared D., Yanckello, Lucille M., Chlipala, George, Hammond, Tyler C., McCulloch, Scott D., Parikh, Ishita, Sun, Sydney, Morganti, Josh M., Green, Stefan J., Lin, Ai-Ling
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713395/
https://ncbi.nlm.nih.gov/pubmed/31461505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0221828
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