Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos

Mechanisms coordinating pancreatic β cell metabolism with insulin secretion are essential for glucose homeostasis. One key mechanism of β cell nutrient sensing uses the mitochondrial GTP (mtGTP) cycle. In this cycle, mtGTP synthesized by succinyl-CoA synthetase (SCS) is hydrolyzed via mitochondrial...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Jesinkey, Sean R., Madiraju, Anila K., Alves, Tiago C., Yarborough, OrLando H., Cardone, Rebecca L., Zhao, Xiaojian, Parsaei, Yassmin, Nasiri, Ali R., Butrico, Gina, Liu, Xinran, Molina, Anthony J., Rountree, Austin M., Neal, Adam S., Wolf, Dane M., Sterpka, John, Philbrick, William M., Sweet, Ian R., Shirihai, Orian H., Kibbey, Richard G.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6713209/
https://ncbi.nlm.nih.gov/pubmed/31315053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.06.058
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