The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein

BACKGROUND: Myeloid cell leukaemia 1 (MCL1) is a pro-survival Bcl-2 family protein that plays important roles in cell survival, proliferation, differentiation and tumourigenesis. MCL1 is a fast-turnover protein that is degraded via an ubiquitination/proteasome-dependent mechanism. Although several E...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Cancer Cell Int
Autores principales: Wu, Lanqin, Lin, Yingying, Feng, Jinan, Qi, Yuanlin, Wang, Xinrui, Lin, Qiaofa, Shi, Wanyan, Zheng, Enrun, Wang, Wei, Hou, Zhenzhu, Lin, Hanbin, Yu, Cheng, He, Yan, Xu, Yan, Yang, Hong, Lin, Ling, Li, Lisheng
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
Materias:
Primary Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6712616/
https://ncbi.nlm.nih.gov/pubmed/31467488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-019-0936-5
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares