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Proteasome subunit α1 overexpression preferentially drives canonical proteasome biogenesis and enhances stress tolerance in yeast

The 26S proteasome conducts the majority of regulated protein catabolism in eukaryotes. At the heart of the proteasome is the barrel-shaped 20S core particle (CP), which contains two β-rings sandwiched between two α-rings. Whereas canonical CPs contain α-rings with seven subunits arranged α1-α7, a n...

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Publicat a:Sci Rep
Autors principals: Howell, Lauren A., Peterson, Anna K., Tomko, Robert J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6712033/
https://ncbi.nlm.nih.gov/pubmed/31455793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48889-5
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