Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin

A longstanding question is how influenza virus evolves to escape human immunity, which is polyclonal and can target many distinct epitopes. Here, we map how all amino-acid mutations to influenza’s major surface protein affect viral neutralization by polyclonal human sera. The serum of some individua...

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Podrobná bibliografie
Vydáno v:eLife
Hlavní autoři: Lee, Juhye M, Eguia, Rachel, Zost, Seth J, Choudhary, Saket, Wilson, Patrick C, Bedford, Trevor, Stevens-Ayers, Terry, Boeckh, Michael, Hurt, Aeron C, Lakdawala, Seema S, Hensley, Scott E, Bloom, Jesse D
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2019
Témata:
Evolutionary Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6711711/
https://ncbi.nlm.nih.gov/pubmed/31452511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49324
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